Identifying research gaps in PIK3CA-mutant breast cancer: a bibliometric analysis of evolving trends and clinical applications

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations are among the most common genetic alterations in breast cancer and have important implications for tumor biology, subtype-specific behavior, and targeted therapy. This study provides a comprehensive bibliometric analysis of global research on PIK3CA mutations in breast cancer, highlighting critical research hotspots and evolving trends. We aim to address the current lack of an integrated understanding in this vital area.