Molecular mechanism of miR-27a-3p targeting FBXW7 regulating the malignant behavior of osteosarcoma cells

Osteosarcoma is a malignant bone tumor with high incidence in children and adolescents, and its prognosis is generally poor. Current comprehensive treatments are limited by tumor recurrence, lung metastasis, and chemoresistance, necessitating further elucidation of the underlying molecular mechanisms and the development of novel therapeutic targets. MicroRNAs (miRNAs) participate in the malignant biological behavior of tumors by post-transcriptionally regulating target genes. Previous studies have shown that miR-27a-3p is highly expressed in osteosarcoma, but its specific function and regulatory mechanism in osteosarcoma remain unclear. This study aims to investigate the effects of miR-27a-3p on the biological behavior of osteosarcoma cells and explore its mechanism of action.