Construction of an actin cytoskeleton-related gene signature for predicting prognosis and therapeutic response in glioblastoma: based on machine learning

Glioblastoma (GBM) is highly aggressive and prone to recurrence, resulting in extremely poor patient outcomes. Evidence suggests that dynamic regulation of the actin cytoskeleton plays a critical role in tumor cell proliferation, invasion, recurrence, and therapy resistance. However, the prognostic value and regulatory mechanisms of actin cytoskeleton-related genes in GBM remain unclear.