Development and multicenter validation of an immunoinflammatory marker-MRI model for pathological complete response after neoadjuvant chemotherapy in invasive breast cancer

Accurate noninvasive prediction of pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in invasive breast cancer (BC) remains challenging. This study aimed to develop and validate a multivariable prediction model integrating clinicopathological variables, immunoinflammatory markers, and multiparametric magnetic resonance imaging (MRI) features for predicting pCR after NAC.