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Intracranial activity of crizotinib: something to rely on?

   
@article{TCR10013,
	author = {Elizabeth Dudnik and Nir Peled},
	title = {Intracranial activity of crizotinib: something to rely on?},
	journal = {Translational Cancer Research},
	volume = {5},
	number = {Suppl 4},
	year = {2016},
	keywords = {},
	abstract = {Central nervous system (CNS) metastases remain a significant problem in the management of patients with ALK-rearranged non-small cell lung cancer (NSCLC). The frequency of CNS involvement in ALK-positive tumors is extremely high; it approaches 25% in treatment naïve patients (1) and rises to 50% in patients treated with crizotinib (2,3). Crizotinib was previously reported to have only minor intracranial activity (4), with poor CNS penetration suggested as the underlying mechanism (5).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/10013}
}