@article{TCR10091,
author = {Bin Nie and Wei Sun and Jian Wang and Jingping Yu and Suping Sun and Xinchu Ni},
title = {Roles of squamous cell cancer antigen, cytokeratin 21-1 fragment, and carcinoembryonic antigen in the diagnosis and prognosis of postoperative locoregional recurrence in esophageal carcinoma},
journal = {Translational Cancer Research},
volume = {5},
number = {5},
year = {2016},
keywords = {},
abstract = {Background: Locoregional recurrence (LR) is the major cause for poor response after radical resection in patients with esophageal carcinoma (EC). Therefore, early diagnosis and positive treatment is crucial for the extension of overall survival in EC patients. We aim to investigate the feasibility of squamous cell cancer antigen (SCC-Ag), cytokeratin 21-1 fragment (CYFRA21-1), and carcinoembryonic antigen (CEA) in the diagnosis of postoperative LR in patients with EC, and the correlation between their expression and the prognosis of the disease.
Methods: Sixty-two EC patients with postoperative LR were included, and thirty normal individuals served as normal control. Serum SCC-Ag, CYFRA21-1and CEA were determined before and one month after treatment. SCC-Ag level was evaluated using chemiluminescent microparticle immunoassay. CYFRA21-1 was determined using the chemiluminescence assay. CEA was determined using the direct chemiluminescence assay. The patients received radiotherapy and/or chemoradiotherapy. The survival rates were measured using Kaplan-Meier method, and was tested using Logrank analysis. Multiple logic regression analysis was used for the analysis of prognostic factors.
Results: Remarkable elevation was noticed in serum SCC-Ag (t=4.79, P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/10091}
}