@article{TCR10094,
author = {Yuan Sun and Qi-Ming An and Xiu-Yun Tian and Zi-Lei Wang and Xiao-Ya Guan and Bin Dong and Min Zhao and Chun-Yi Hao},
title = {Fusobacterium nucleatum infection is correlated with tumor metastasis and postoperative survival of colorectal cancer patients in China},
journal = {Translational Cancer Research},
volume = {5},
number = {5},
year = {2016},
keywords = {},
abstract = {Background: In western patients, the association of Fusobacterium nucleatum (F. nucleatum) with colorectal carcinoma (CRC) has been established, but the underlying mechanism remains unclear. There is no report about F. nucleatum infection status and its potential role in CRC patients in China. This study aimed to evaluate infection status and infection load of F. nucleatum and its correlation with clinicopathological features and prognosis of CRC patients in China.
Methods: Fresh tumor and adjacent normal mucosa tissues were obtained at surgery from 152 CRC patients, and then DNA was assayed for infection of F. nucleatum by quantitative PCR. Then the association of infection with clinicopathological features and prognosis was evaluated. In addition, MMP9, MMP11, CD45RO and FOXP3 expression levels was assessed by immunohistochemistry to explore the potential role of F. nucleatum.
Results: The infection rate of F. nucleatum in CRC tissues was significantly higher than that in adjacent normal tissues (77.6% vs. 57.2%, P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/10094}
}