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Novel therapeutic strategies against cancer and chronic infection by targeting P-selectin glycoprotein ligand-1 as an immune T cells response regulator

  
@article{TCR10162,
	author = {Elisa Ramos-Sevillano and Jose Yuste},
	title = {Novel therapeutic strategies against cancer and chronic infection by targeting P-selectin glycoprotein ligand-1 as an immune T cells response regulator},
	journal = {Translational Cancer Research},
	volume = {5},
	number = {Suppl 4},
	year = {2016},
	keywords = {},
	abstract = {P-selectin glycoprotein ligand-1 (PSGL-1) is a homodimeric mucin-like glycoprotein primarily restricted to cells of hematopoietic origin. Although, it may be present on some non-immune cells such as epithelial cells lining the fallopian tube, microvascular endothelial cells, and platelets, PSGL-1 is broadly expressed on most immune cells including neutrophils, monocytes, dendritic cells and lymphocytes (1,2). PSGL-1 on leukocytes mediates interactions with P-selectin and E-selectin present in activated endothelium with a major role in leukocyte adhesion and transmigration as it is responsible for the initial steps of the extravasation cascade (1,2).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/10162}
}