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CIS is a negative regulator of IL-15-mediated signals in NK cells

   
@article{TCR10166,
	author = {Cristina Bottino and Alessandra Dondero and Alessandro Moretta and Roberta Castriconi},
	title = {CIS is a negative regulator of IL-15-mediated signals in NK cells},
	journal = {Translational Cancer Research},
	volume = {5},
	number = {Suppl 4},
	year = {2016},
	keywords = {},
	abstract = {The cytokine-inducible SH2-containing protein (CIS, encoded by Cish) is a member of the suppressors of cytokine signaling (SOCS), a family of intracellular proteins that have been show to regulate the activity of a variety of cytokine and growth factor receptors (1). Similar to the other members, CIS presents a central SH2-domain able to interact with phosphotyrosine residues and a SOX box motif that recruits the ubiquitin-transferase system (u-ts) and directs targeted proteins to proteasomal degradation.},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/10166}
}