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Clinical data and role of ceritinib a second-generation ALK tyrosine kinase inhibitor for the treatment of ALK positive non-small cell lung cancer

   
@article{TCR10541,
	author = {Sacha I. Rothschild},
	title = {Clinical data and role of ceritinib a second-generation ALK tyrosine kinase inhibitor for the treatment of ALK positive non-small cell lung cancer},
	journal = {Translational Cancer Research},
	volume = {5},
	number = {Suppl 6},
	year = {2016},
	keywords = {},
	abstract = {Rearrangements in anaplastic lymphoma kinase (ALK) gene and echinoderm microtubule-associated protein-like 4 (EML4) gene were first described in 2007. This genomic aberration is found in about 2–8% of non-small cell lung cancer (NSCLC) patients. In patients with adenocarcinoma lacking EGFR and KRAS mutations, the prevalence of EML4-ALK translocation could be as high as 42.8% (1). In these patients, ALK rearrangements serve as a key and strong oncogenic driver for NSCLC and represent a critical therapeutic target susceptible to targeted ALK kinase inhibition (2,3).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/10541}
}