@article{TCR10744,
author = {Shaoyu Zhou and James E. Klaunig},
title = {Interplay between MMP-8 and TGF-β1 and its role in regulation of epithelial to mesenchymal transition in hepatocellular carcinoma},
journal = {Translational Cancer Research},
volume = {5},
number = {Suppl 6},
year = {2016},
keywords = {},
abstract = {The transdifferentiation of epithelial cells into motile mesenchymal cells is a multistep biological process known as epithelial-mesenchymal transition (EMT). The epithelial to mesenchymal transition is characterized by the de-differentiation of epithelial cells to a mesenchymal-like or mesenchymal phenotype with the loss of epithelial markers such as adherence junction component E-cadherin and cytokeratin of the intermediate filament system, accompanied by the increased expression of mesenchymal proteins such as N-cadherin and vimentin. EMT is essential in embryonic development and tissue repair, and also plays a critical role in the progression of cancer where cells lose cell to cell adhesions and acquire increased motility to spread into surrounding and distant tissues (1).},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/10744}
}