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PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression

   
@article{TCR11305,
	author = {Kim A. Brogden and Shireen Vali and Taher Abbasi},
	title = {PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression},
	journal = {Translational Cancer Research},
	volume = {5},
	number = {Suppl 7},
	year = {2016},
	keywords = {},
	abstract = {Programmed death-ligand 1 (PD-L1) is a 33.28 kDa protein on the surface of many immune and non-immune cells (1-3). Its primary function as a co-stimulatory molecule is well documented (4). PD-L1 serves as an ‘immune checkpoint’ and it binds to receptor programmed death-1 (PD-1) to regulate immune responses among antigen presenting cells and T-cells. Unfortunately, this exact mechanism is exploited by tumor cells where increased expression of PD-L1 results in immunosuppression of the adaptive tumor response by inhibiting T-cell proliferation, reducing T-cell survival, inhibiting cytokine release, and promoting T-cell apoptosis (5,6). This leads to T-cell exhaustion and immunosuppression in the tumor microenvironment (7).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/11305}
}