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Heparin-induced thrombocytopenia: new insights into the immune response

   
@article{TCR12057,
	author = {Benilde Cosmi},
	title = {Heparin-induced thrombocytopenia: new insights into the immune response},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 1},
	year = {2017},
	keywords = {},
	abstract = {Heparin induced thrombocytopenia (HIT) is an immuno mediated adverse reaction to heparin (both unfractionated and low molecular weight) due to the development of IgG antibodies against a self antigen, that is the complex of platelet factor 4 (PF4) and heparin or other polyanions. The IgG/heparin-PF4 immunocomplexes can cross-link with the Fcγ receptor IIa (FcγRIIa) on platelet surface. As a consequence, platelets are activated with intravascular aggregation and consumption, leading to thrombocytopenia. However, a paradoxical prothrombotic state ensues with coagulation activation and life-threatening venous and/or arterial thrombotic complications (1).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/12057}
}