@article{TCR122350,
author = {Yiyang Chen and Muchen Ren and Sihui Liu and Tianyi Wang and Heyang Zhang and Junju He and Hanping Shi},
title = {Association Between the Systemic Immune-Inflammation Index and Overall Survival in Patients With Leukemia: A Multicenter Cohort Study},
journal = {Translational Cancer Research},
volume = {0},
number = {0},
year = {2026},
keywords = {},
abstract = {Background: The systemic immune-inflammation index (SII; platelet × neutrophil / lymphocyte) is a well-established prognostic marker in solid tumors, but its clinical significance in leukemia remains unclear, where peripheral blood cytopenias may primarily reflect bone marrow failure rather than conventional cancer-related inflammation.Methods: We retrospectively analyzed 609 leukemia patients from a multicenter registry, split into training (n=427) and validation (n=182) cohorts. Baseline SII was calculated before therapy. A data-derived SII threshold was identified in the training cohort using maximally selected rank statistics. Overall survival was assessed using Kaplan–Meier curves, Cox regression, and restricted cubic splines. A nomogram was constructed based on the multivariable Cox model and internally evaluated using bootstrap calibration for 1- and 3-year survival.Results: An SII cutoff of 173.56 significantly separated survival (log-rank P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/122350}
}