@article{TCR122396,
author = {Jing Long and Youzhi Wang and Mengqi Zou and Gangyong Jiang and Zhongwei Jiang and Wanxiao Peng},
title = {Anti-Lipid Peroxidation Restores Schwann Cell Repair Phenotype and Attenuates PNI-like Behavior in Oral Squamous Cell Carcinoma},
journal = {Translational Cancer Research},
volume = {0},
number = {0},
year = {2026},
keywords = {},
abstract = {Background: Perineural invasion (PNI) is a critical feature of oral squamous cell carcinoma (OSCC), in which Schwann cells are increasingly recognized as active contributors rather than passive structures. However, the mechanisms underlying Schwann cell phenotypic remodeling in the tumor microenvironment remain incompletely understood. This study aimed to investigate whether OSCC-derived signals induce lipid peroxidation and repair-associated phenotypic remodeling in Schwann cells that promote PNI-like tumor cell behavior, and whether inhibiting lipid peroxidation can attenuate these effects.Methods: An OSCC-conditioned microenvironment was established to investigate whether tumor-derived signals induce lipid peroxidation and phenotypic changes in human Schwann cells (hSCs). Redox status was assessed by LDH, MDA, GSH, and C11-BODIPY assays. Repair-associated markers (c-Jun and NGFR) were evaluated by Western blot, and RSL3 was used as a positive inducer of lipid peroxidation. Schwann cell-conditioned medium (SCM) was applied to assess its effects on OSCC cell migration and invasion. Ferrostatin-1 (Fer-1) was used to inhibit lipid peroxidation.Results: OSCC-conditioned medium induced significant lipid peroxidation and redox imbalance in hSCs, as evidenced by increased LDH and MDA levels and decreased GSH (all P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/122396}
}