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The CXCL12/CXCR4 pathway or the autocrine proliferative loop of the glioblastoma stem cells

   
@article{TCR12676,
	author = {Bernard Rogister},
	title = {The CXCL12/CXCR4 pathway or the autocrine proliferative loop of the glioblastoma stem cells},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 2},
	year = {2017},
	keywords = {},
	abstract = {Despite multimodal therapy (the classical Stupp’s protocol) including surgical resection (as large as possible), radiotherapy and chemotherapy, glioblastoma (GBM) remain a burden as the global survival rate at two years reaches barely 9% of patients (1). This situation is mainly a consequence of a systematic recurrence and this recurrence is itself a consequence of various causes, acting alone or synergistically: heterogeneous nature of the disease (2), the presence of the brain-blood barrier which impedes the potentially active drugs to get into the brain (3), the lack of targeted chemotherapeutic molecules and the persistence of GBM-initiating or stem cells (GSC) (4).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/12676}
}