@article{TCR12897,
author = {Zhansheng Zhu and Lanjun Feng and Futian Li and Yuanzhi Xue and Chaoyang Li and Huiping Wang},
title = {A novel functional indel polymorphism within long non-coding RNAs growth arrest specific 5 conferred risk for cervical squamous cell carcinoma in Chinese Han populations},
journal = {Translational Cancer Research},
volume = {6},
number = {2},
year = {2017},
keywords = {},
abstract = {Background: Growth arrest specific 5 (GAS5) has been reported as a tumor repressor in multiple cancers, but the role of the indel polymorphism rs145204276 within GAS5 in cervical squamous cell carcinoma (CSCC) susceptibility has not been well established yet.
Methods: A hospital based case-control study in Shehong and Xuzhou centers was performed to evaluate the potential association of the indel polymorphism rs145204276 within GAS5 with CSCC risk, and further in vivo and in vitro assays were applied to confirm the plausible association.
Results: When taking ins/ins genotype as reference in codominant model, ins/del genotype confers a slightly increased risk for CSCC [odds ratio (OR) =1.27, 95% confidence interval (CI): 1.04–1.52, P=0.02], the homozygous del/del genotype shows an increased risk for CSCC (OR =2.24, 95% CI: 1.60–2.97, P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/12897}
}