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Upfront radiation versus EGFR-TKI: which is the best approach for EGFR-mutated NSCLC patients with brain metastasis?

  
@article{TCR13314,
	author = {Francesco Passiglia and Christian Rolfo},
	title = {Upfront radiation versus EGFR-TKI: which is the best approach for EGFR-mutated NSCLC patients with brain metastasis?},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 3},
	year = {2017},
	keywords = {},
	abstract = {In The Journal of Clinical Oncology, William J. Magnuson (1)  and colleagues have recently reported the results of a multicenter retrospective analysis comparing the impact of three different treatment strategies on survival outcomes of 351 patients with epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) and brain metastases (BM). Treatment options included stereotactic radiosurgery (SRS) followed by EGFR-TKI (n=100), whole-brain radiotherapy (WBRT) followed by EGFR-TKI (n=120), or EGFR-TKI followed by SRS or WBRT at the time of intracranial progression (n=131). Results showed a significantly longer median overall survival (OS) in patients who received upfront SRS (46 months) as compared to WBRT (30 months) or upfront TKI (25 months) (P},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/13314}
}