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Epigenetic profiling of tumor infiltrating lymphocytes

   
@article{TCR15006,
	author = {Jill E. Slansky and Laura D. Harmacek and Brian P. O’Connor},
	title = {Epigenetic profiling of tumor infiltrating lymphocytes},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 6},
	year = {2017},
	keywords = {},
	abstract = {Blocking T cell inhibitory signals, or “checkpoint blockade”, has provided unprecedented clinical results for therapy of cancer (1). Antibodies that block negative interactions between programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) allow activation of T cells that recognize tumor antigens and promote immune destruction of the tumor. To determine the activities of T cells of tumor infiltrating lymphocytes (TILs), and to determine which patients will most effectively respond to checkpoint blockade therapies, Schietinger and colleagues developed a novel inducible autochthonous tumor in AST × CreERT2 mice. In this system, they successfully analyzed TIL activity and chromatin remodeling during tumor development (2,3).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/15006}
}