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The need for speed: how PD1-blockade only works if T cells are properly activated

   
@article{TCR15195,
	author = {Johannes vom Berg and Sebastian Kobold},
	title = {The need for speed: how PD1-blockade only works if T cells are properly activated},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 6},
	year = {2017},
	keywords = {},
	abstract = {Programmed death receptor 1 (PD1) has been identified as critical negative regulator of T cell activity (1). While PD1-mediated T cell inhibition is an important mechanism to prevent autoimmunity, cancer and chronic infectious diseases may usurp this regulation mechanism to drive immune suppression (2). In fact, the PD1-PD-L1 axis is one of the major axis used by a variety of cancer types to inhibit T cell responses and function (3). As a direct consequence, strategies interfering with PD1-signaling such as antibodies have entered the clinic and are approved in a number of indications (4). A remarkable aspect being that these so-called check point inhibitors also show significant activity in such clinical situations where any other therapy had previously failed (5).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/15195}
}