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CAR-T cell in vivo tracking method using PET scan with the reporter gene and new investigational tracer [18F] FHBG

   
@article{TCR15199,
	author = {Tsubasa Miyazaki and Hitoshi Aiyama and Eiichi Ishikawa},
	title = {CAR-T cell in vivo tracking method using PET scan with the reporter gene and new investigational tracer [18F] FHBG},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 6},
	year = {2017},
	keywords = {},
	abstract = {Recent development of cancer immunotherapy, and CAR-T cell therapy in particular, attracts considerable attention among researchers. In antitumor immunity, cytotoxic T lymphocytes (CTLs) specifically recognize tumor-associated antigens (TAAs) in an MHC-class I-restricted manner and attack tumor cells. CTL activation and its clonal expansion require co-stimulatory receptors such as CD28, 4-1BB and OX40, and CTL stimulatory cytokine including IL-2 and IFNγ in addition to antigen recognition. However, tumor cells escape from the immune surveillance via decreased expression of MHC class 1, increased expression of co-inhibitory molecule, inhibitory cytokine production and accumulation of inhibitory immune cells during in vivo growth. CAR gene-designated extracellular binding domain consists of a target-specific antibody or a targeting ligand fused with the intracellular activating CD3zeta chain and the co-stimulatory molecule gene (1).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/15199}
}