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Does ipilimumab show an increased clinical benefit when combined in sequence with chemotherapy?

   
@article{TCR17474,
	author = {Tatsuya Nagano and Motoko Tachihara and Yoshihiro Nishimura},
	title = {Does ipilimumab show an increased clinical benefit when  combined in sequence with chemotherapy?},
	journal = {Translational Cancer Research},
	volume = {7},
	number = {Suppl 1},
	year = {2017},
	keywords = {},
	abstract = {Ipilimumab is a fully human monoclonal antibody against cytotoxic T-cell lymphocyte antigen-4 (CTLA-4), which is not expressed by resting T cells and is only detected in activated T cells (1). CTLA-4 is known as a crucial negative regulator of the immune system, as it binds to B7 ligands (CD80/CD86) on antigen-presenting cells (APCs) with a high affinity and competes with costimulatory receptor CD28 on T cells for binding with B7 ligands (2). Ipilimumab works by blocking the binding of CTLA-4 to its ligands and augments T cell activation, leading to tumor regression (3). In contrast to conventional T (Tconv) cells, regulatory T (Treg) cells, which suppress aberrant immune responses, including the anti-tumor immune response, constitutively express CTLA-4 (4). Therefore, ipilimumab evokes effective tumor immunity by killing effector Treg cells or attenuating their suppressive activity.},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/17474}
}