TY  - JOUR
AU  - Otsuka, Motoyuki
AU  - Ishibashi, Rei
AU  - Tanaka, Eri
AU  - Seimiya, Takahiro
AU  - Suzuki, Tatsunori
AU  - Sekiba, Kazuma
AU  - Yamagami, Mari
AU  - Ohno, Motoko
AU  - Kishikawa, Takahiro
AU  - Koike, Kazuhiko
PY  - 2017
TI  - A tiny but crucial player bridging microbes and colonic  carcinogenesis
JF  - Translational Cancer Research; Vol 6, Supplement 9 (December 14, 2017): Translational Cancer Research
Y2  - 2017
KW  - 
N2  - Colorectal cancer (CRC) is one of the most common malignancies in the world (1). The probability of suffering from CRC is approximately 4–5%, and the risk of developing CRC is associated with characteristics such as age, chronic disease history, and lifestyle (2). CRC is caused by mutations in oncogenes, tumor-suppressor genes, and genes related to DNA repair mechanisms. The underlying pathogenic mechanisms are threefold; namely, chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP). In CRC, common mutations, chromosomal changes, and translocations reportedly affect important intracellular signaling pathways [WNT, mitogen activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K), transforming growth factor (TGF)-β, and TP53] (2). In addition to genetic mutations, alterations in non-coding RNAs, such as microRNAs, also contribute to carcinogenesis.
UR  - https://tcr.amegroups.org/article/view/17512