@article{TCR17572,
author = {Andrew Rowland and Michael J. Sorich},
title = {Preface to Precision Dosing of Targeted Anti-Cancer Drugs},
journal = {Translational Cancer Research},
volume = {6},
number = {Suppl 10},
year = {2017},
keywords = {},
abstract = {Small molecule protein kinase inhibitors (KIs) and anti-neoplastic monoclonal antibodies (mAbs) are rapidly expanding classes of non-cytotoxic or ‘targeted’ antineoplastic drugs that are effective at treating numerous malignancies, including previously difficult to treat forms of cancers. However, variability in disposition causes inter-individual variability in drug exposure that is inadequately addressed by the standard fixed-dose schedule of administration (1). Accordingly, precision dosing has great potential to maximise therapeutic response, minimise adverse drug reactions (ADRs), and improve cost-effectiveness of these expensive drugs.},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/17572}
}