@article{TCR18283,
author = {Dorota Kiprian and Bozena Czarkowska-Paczek and Aleksandra Wyczalkowska-Tomasik and Malgorzata Fuksiewicz and Beata Kotowicz and Leszek Paczek},
title = {Radiotherapy and radiochemotherapy increase serum levels of pro-inflammatory interleukin-6 and C-reactive protein in patients with head and neck cancers},
journal = {Translational Cancer Research},
volume = {7},
number = {1},
year = {2018},
keywords = {},
abstract = {Background: Inflammation influences cancer growth and treatment susceptibility. We investigated the influence of radiochemotherapy and radiotherapy on serum interleukine-6 (IL-6), C-reactive protein (CRP), and transforming growth factor-β (TGF-β) levels in patients with head and neck cancers.
Methods: Of 26 patients enrolled, 8 received radiotherapy (SIB-IMRT, 2.25 Gy/fraction, 30 fractions) and 18 received radiochemotherapy [cisplatin 100 mg/m2 and SIB–IMRT (n=9) or IMRT (2 Gy/fraction, 35 fractions, n=9)]. The control group consisted of healthy individuals. IL-6 and TGF-β concentrations were determined by ELISA and CRP by an immunoturbidimetric method before treatment, 2 and 4 weeks after treatment started, at the end of treatment, and 4 weeks post-treatment.
Results: IL-6 levels were higher in the treatment group compared to controls and increased at all-time points compared to pre-treatment levels (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/18283}
}