@article{TCR18768,
author = {Shu Lin and Lin Zhao and Xinyue Song and Jing Zhang and Yan Wang and Longyang Jiang and Lifeng Yu and Jia Bi and Minjie Wei},
title = {Prognostic value of miRNA-181a in human colorectal cancer evaluated by in situ hybridization},
journal = {Translational Cancer Research},
volume = {7},
number = {1},
year = {2018},
keywords = {},
abstract = {Background: Colorectal cancer (CRC) is one of the most common cancers in the world and the 5th leading cause of cancer death in China. CRC affects the gastrointestinal tract and has a high mortality rate. Recent studies have demonstrated the abnormal expression of miRNA-181a in a wide variety of tumors. However, the clinical significance of miRNA-181a in CRC is still unclear.
Methods: The detection of miRNA-181a was performed by probe hybridization using 3' and 5' end LNA-modified DNA probes. And we evaluated the survival probabilities by the Kaplan-Meier method and the log-rank test. Furthermore, the univariate and multivariate Cox proportional hazard regression model were used for assessing the association of the miRNA-181a expression and prognosis.
Results: MiRNA-181a was highly expressed in CRC (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/18768}
}