@article{TCR20635,
author = {Shuwei Wang and Zhongyang Ding and Jiandong Tang and Gan Li},
title = {The association of interleukin-6 gene polymorphism and risk of colorectal cancer in Chinese patients},
journal = {Translational Cancer Research},
volume = {7},
number = {2},
year = {2018},
keywords = {},
abstract = {Background: Clinical and experimental data have strongly revealed a vital role of interleukin-6 (IL-6) in the development of both sporadic and colitis-associated colorectal cancer (CRC) development. The aim of our study is to discover the association between CRC risk in Chinese people and one variant (rs1800795) in IL-6 gene which was reported to significantly associate with CRC risk in Caucasian population.
Methods: We included 186 CRC patients and 200 age- and gender- matched control individuals from the Wuxi Traditional Chinese Hospital. We used one customized assay of IL6-174G/C from Applied Biosystems to genotype one IL-6 gene polymorphisms (rs1800795) through real time-RCR method. All statistical analyses were conducted with SPSS 17.0 by Student’s t-test, χ2 test, Fisher’s exact test or logistic regression.
Results: Finally, our studies showed the C allele would significant increase the CRC risk in female [odds ratio (OR): 1.741, 95% confidence interval (CI): 1.037, 2.924, P value: 0.035] and non-smokers (OR: 2.425, 95% CI: 1.626, 3.617, P value: },
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/20635}
}