@article{TCR22080,
author = {Catherine S. Spina},
title = {Androgen deprivation therapy and radiation therapy for prostate cancer: the mechanism underlying therapeutic synergy},
journal = {Translational Cancer Research},
volume = {7},
number = {Suppl 6},
year = {2018},
keywords = {},
abstract = {The first report of modulation of androgens in men with prostate cancer was conducted by Huggins and Hodges in 1941 (1). In a cohort of 8 men with metastatic prostate cancer including osseous metastases, administration of estradiol and/or surgical castration resulted in a durable reduction of alkaline phosphate levels, a marker of osseous disease burden. By surgically eliminating testicular production of testosterone or negatively regulating the hypothalamic-pituitary-gonadal axis through estrogen administration, this was the first demonstration that androgen suppression can induce a measurable biochemical disease response.},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/22080}
}