TY  - JOUR
AU  - Chen, Fei
AU  - Wang, Xiao-Guang
AU  - Qi, Li-Feng
AU  - Mo, Juan-Fen
AU  - Zhong, Zheng-Xiang
PY  - 2018
TI  - A novel nanoprobe-based assay for detecting K-ras mutations in plasma and stool samples from patients with pancreatic cancer: value in diagnosis and prognosis evaluation
JF  - Translational Cancer Research; Vol 7, No 4 (August 31, 2018): Translational Cancer Research
Y2  - 2018
KW  - 
N2  - Background: To develop a novel nanoprobe-based assay for detecting K-ras mutations in plasma and stool samples from patients with pancreatic cancer, and assess its value in the diagnosis and prognosis evaluation of this malignancy.  Methods: Fifty-eight pancreatic cancer, 18 chronic pancreatitis, 7 pancreatic cystadenoma, 5 pancreatic cyst, 2 solid pseudopapillary tumor of the pancreas patients, who were treated at the Second Affiliated Hospital of Jiaxing University from June 2013 to October 2015. Thirty-one healthy volunteers were as normal controls. Blood and stool samples were collected from these subjects to detect the K-ras mutation status using a novel nanoprobe-based assay, assess its diagnostic accuracy and analysis the relation between the clinicopathological characteristics and survival in pancreatic cancer.  Results: The detection rates of K-ras mutations in stool and plasma samples from patients with pancreatic cancer were 79.3% and 43.1%, respectively, both of which were significantly higher than those for patients with benign pancreatic diseases (15.6% and 6.3%, respectively; P
UR  - https://tcr.amegroups.org/article/view/22758