@article{TCR22831,
author = {Li Zhang and Ning Zhang and Xinyu Qu and Yaming Li and Qifeng Yang},
title = {Huaier extract exerts immunomodulatory effects by regulating serum cytokines in breast cancer},
journal = {Translational Cancer Research},
volume = {7},
number = {4},
year = {2018},
keywords = {},
abstract = {Background: Huaier extract, a traditional Chinese medicine (TCM) with a 1,600-year history, has recently become a complementary anticancer drug in China. Previous studies have demonstrated that Huaier extract has multiple anticancer effects. However, whether Huaier extract has immunomodulatory effects on serum cytokine profiles in breast cancer patients remains unknown.
Methods: Thirty-eight serum specimens were collected from 19 female breast cancer patients who were treated with Huaier extract before surgery in Qilu Hospital, and serum cytokines were analyzed by Bio-Plex ProTM cytokine assays. Murine breast cancer model was built to further verify the immunomodulatory effects of Huaier extract, and serum cytokine levels were detected by enzyme linked immunosorbent assay (ELISA) assay and pulmonary metastasis were counted.
Results: In this study, we found that Huaier extract significantly decreased the MCP-1, MIP-1β levels (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/22831}
}