@article{TCR23187,
author = {Long Zhang and Bin Yang and Xiaoli Li and Yunjing Zhang and Jinping Zhao and Wenbin Wang and Xiaohui Yu and Zhenhua Zhai and Hongzhi Sun},
title = {The targeting of endoglin on vascular endothelial cells affects the infiltration of M2 macrophages into the breast cancer microenvironment by modulating the interleukin-6 (IL-6) level},
journal = {Translational Cancer Research},
volume = {7},
number = {4},
year = {2018},
keywords = {},
abstract = {Background: The effect and underlying mechanisms of endoglin on angiogenesis and immunity during tumour progression were investigated.
Methods: Differences in the growth of established EO771 breast tumours between endoglin-knockout (Eng-iKOe) and control mice were evaluated. The tumour tissues were harvested on the day 7th and 14th after engraftment, at which times the growth differences between the groups were significant. The expression of markers of angiogenesis (CD31), endoglin (CD105), tumour associated macrophages (TAMs) (F4/80) and M2 macrophages (CD206) and of interleukin-6 (IL-6), IL-10, and IL-6/Janus kinase 2 (JAK2)/signal transducer and activators of transcription 3 (STAT3) proteins in tumour tissues of Eng-iKOe and control mice were evaluated.
Results: We found that tumour angiogenesis and growth were both inhibited in the Eng-iKOe group relative to the control group on day 7, whereas, no significant between-group difference was observed on day 14. Moreover, in breast cancer tissues of the Eng-iKOe group, the numbers of M2 macrophages were significantly decreased on day 7 and increased on day 14, and the expression of IL-6 and IL-10 were lower on day 7 and higher on day 14. Positively strong correlations were found between the IL-6 level and the number of M2 macrophages both on days 7 (P=0.017, r=0.80) and 14 (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/23187}
}