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EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients

   
@article{TCR24920,
	author = {Niki Karachaliou and Manuel Fernandez-Bruno and Jillian Wilhelmina Paulina Bracht and Rafael Rosell},
	title = {EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients},
	journal = {Translational Cancer Research},
	volume = {8},
	number = {Suppl 1},
	year = {2018},
	keywords = {},
	abstract = {Identification of epidermal growth factor receptor (EGFR) as a molecular target has radically changed the treatment of metastatic non-small cell lung cancer (NSCLC) from standard chemotherapy to personalized, targeted therapy. First-, second- and third-generation EGFR tyrosine kinase inhibitors (TKIs) are now available for the treatment of EGFR-mutant NSCLC patients. This review will focus on the clinical development of first- and second-generation EGFR TKIs. We will emphasize on essential points like the head-to-head comparison among EGFR TKIs, their activity on brain metastases, mechanisms of resistance, as well as their combination with anti-angiogenic compounds, other targeted therapies, or immunotherapy. The efficacy of first- and second-generation EGFR TKIs in early-stage EGFR-mutant NSCLC will be also finally reviewed.},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/24920}
}