@article{TCR27314,
author = {Guan-Hui Zhou and Jun-Hui Sun and Yue-Lin Zhang and Tan-Yang Zhou and Chun-Hui Nie and Tong-Yin Zhu and Jing Ai and Sheng-Qun Chen and Bao-Quan Wang and Zi-Niu Yu and Hong-Liang Wang and Li-Ming Wu and Li-Ming Chen and Shu-Sen Zheng},
title = {Transcatheter embolization of hepatocellular carcinoma with epirubicin-loaded DC beads in Chinese patients},
journal = {Translational Cancer Research},
volume = {8},
number = {1},
year = {2019},
keywords = {},
abstract = {Background: This study evaluated the safety and efficacy of transcatheter chemoembolization with drug eluting beads (DEB-TACE) and compared it to the conventional TACE (cTACE) therapy method for hepatocellular carcinoma (HCC) in Chinese patients.
Methods: Seventy-four patients were treated with DEB-TACE using the DC bead, and 80 patients were treated with cTACE for HCC. The modified response evaluation criteria in solid tumors (mRECIST) criteria were used to evaluate clinical response, with adverse events assessed according to the Common Terminology Criteria for Adverse Events (CTCAE).
Results: Post-TACE, 9 patients (12.2%) achieved complete response (CR) and 44 (59.5%) achieved partial response (PR), with an overall tumor response rate (ORR) of 71.6% in the DEB-TACE group. Twelve patients (15%) achieved CR, and 38 (47.5%) achieved PR, with an ORR of 62.5% in the cTACE group. However, there was no significant difference in ORR between the two groups (P=0.229). Univariate logistic regression analysis determined that more than 3 nodules, higher Barcelona clinic liver cancer (BCLC) stage, portal vein invasion, previous chemotherapy (cTACE), and previous surgery were correlated with a worse ORR. Most common adverse events were not severe.
Conclusions: DEB-TACE by DC bead was efficient and well-tolerated compared to cTACE in Chinese HCC patients. However, the present study showed no significant difference in ORR between the DEB-TACE and cTACE in the patient group with HCC. The BCLC stage, number of nodules, portal vein invasion, cTACE, and surgery history could possibly be a predictive factor for HCC treatment response.},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/27314}
}