@article{TCR2949,
author = {Ronald F. Young and Francisco Li and Sandra Vermeulen and Daniel A. Clayton and Robert D. Hesselgesser},
title = {Gamma knife pallidotomy for treatment of Parkinson’s disease: long term results, clinical study},
journal = {Translational Cancer Research},
volume = {3},
number = {4},
year = {2014},
keywords = {},
abstract = {Background: Deep brain stimulation (DBS) is now the preferred surgical treatment for advanced Parkinson’s disease (PD). Some patients however are not suitable candidates for an open surgical procedure or may prefer a procedure that does not include the permanent implantation of hardware. For such patients, gamma knife pallidotomy (GKP) may be a suitable alternative.
Objective: The goal of this report was to describe the safety and effectiveness of posteroventral pallidotomy (GKP) performed with the Leksell gamma knife (LGK) for the treatment of advanced PD.
Methods: Forty patients underwent a total of 51 GKP procedures with LGK between August 1993 and June 2009. Twenty nine patients underwent a unilateral procedure whereas 11 underwent bilateral procedures.
Results: There were statistically significant improvements in off-medication unified Parkinson’s disease rating scale (UPDRS) scores for total scores (18.4%), motor scores (18.2%), tremor(72.4%) rigidity (51.2%) and bradykinesia (23.4%) scores and also for on medication dyskinesia scores (70.0%.) Bilateral procedures produced an additional incremental improvement in symptoms. Two patients suffered permanent complications.
Conclusions: GKP offers a safe and effective procedure for the treatment of advanced PD. Although probably not as effective as DBS, it is particularly applicable to patients who may not be candidates for DBS.},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/2949}
}