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Sideroflexin1 as a novel tumor marker independently predicts survival in lung adenocarcinoma

   
@article{TCR30374,
	author = {Qijiu Chen and Rong Wang and Jianyong Zhang and Liang Zhou},
	title = {Sideroflexin1 as a novel tumor marker independently predicts survival in lung adenocarcinoma},
	journal = {Translational Cancer Research},
	volume = {8},
	number = {4},
	year = {2019},
	keywords = {},
	abstract = {Background: Targeted therapy for lung cancers is based on prognostic genes and needs more investigation. No study has yet evaluated the effects of Sideroflexin1 (SFXN1) on lung cancer.
Methods: Data were analyzed from large patient cohorts in the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO).
Results: The mRNA and protein expression of SFXN1 is apparently upregulated in lung adenocarcinoma (LUAD) tissues. Among LUAD patients, upregulated SFXN1 mRNA expression can independently predict unfavorable overall survival (OS, P=0.006) and recurrence-free survival (RFS; P=0.003). In addition, detection data from DNA copy number alterations (CNAs) showed that 164 (32.03%) of the 512 cases had copy number loss (−2 and −1), while 121 (23.63%) of the cases had copy number amplification (+1 and +2). We also found a weak negative correlation between the methylation status of one CpG site (chr5: 174, 944, 791–174, 944, 793) and SFXN1 expression (P},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/30374}
}