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Lomustine and temozolomide for newly diagnosed glioblastoma with methylated MGMT promoter: Lessons from the CeTeG/NOA-09 trial

   
@article{TCR30864,
	author = {Ivo W. Tremont-Lukats and Bin S. Teh},
	title = {Lomustine and temozolomide for newly diagnosed glioblastoma with methylated MGMT promoter: Lessons from the CeTeG/NOA-09 trial},
	journal = {Translational Cancer Research},
	volume = {8},
	number = {Suppl 6},
	year = {2019},
	keywords = {},
	abstract = {The Neuro-Oncology Working Group of the German Cancer Society (Neuroonkologische Arbeitsgemeinshaft, NOA), studied the effect of lomustine (CCNU, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) and temozolomide together to treat patients with newly diagnosed glioblastoma with a methylated O6-methylguanine DNA methyltransferase (MGMT) promoter (1). This strategy needed testing after the encouraging results of a phase II trial (2), and the synergistic or additive effect between temozolomide and lomustine since nitrosoureas have additional non-alkylating effects on DNA and cell replication (3).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/30864}
}