@article{TCR32531,
author = {Jinling Bi and Yong Huang and Yulong Liu},
title = {Effect of NOP2 knockdown on colon cancer cell proliferation, migration, and invasion},
journal = {Translational Cancer Research},
volume = {8},
number = {6},
year = {2019},
keywords = {},
abstract = {Background: Proliferation-associated nucleolar protein p120 (NOP2) has been proven to be a promising tumor cell maker, but it has not been specifically studied in colon cancer. This study aims to investigate the role and action mechanism of NOP2 in colon cancer.
Methods: Fluorescence quantitative PCR and western blot assays were used to evaluate the expression of NOP2. NOP2 siRNA was transfected into HCT116, LOVO, and CCK-8 cells, and transwell assays were performed to evaluate the cell proliferation, migration, and invasion. Transcriptome sequencing of both the NOP2 knockdown and negative control (NC) groups was performed.
Results: NOP2 expression is significantly upregulated in colon cancer tissues and cells compared with that in the healthy controls. The proliferation, migration, and invasion of the colon cancer cells were significantly suppressed in the NOP2 knockdown group compared with those in the NC group (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/32531}
}