@article{TCR33668,
author = {Dehui Xu and Qingjie Cui and Yujing Xu and Zeyu Chen and Wenjie Xia and Yanjie Yang and Dingxin Liu},
title = {Plasma enhance drug sensitivity to bortezomib by inhibition of cyp1a1 in myeloma cells},
journal = {Translational Cancer Research},
volume = {8},
number = {8},
year = {2019},
keywords = {},
abstract = {Background: Drug resistance is one of the major problems encountered in clinical therapy of multiple myeloma treatment. Combination treatment with several drugs may increase the sensitivity and overcome drug resistance.
Methods: Here, we combined chemotherapy with a newly developed technology, cold atmospheric plasma, to enhance drug sensitivity.
Results: We found that plasma treatment had a synergistic anti-cancer effect with a first line drug (bortezomib). Based on our previous study, we further found that plasma treatment could inhibit Notch pathway and down-regulate cyp1a1 expression and enzyme activity, which contributing to the enhanced drug sensitivity to bortezomib after combination of bortezomib with gas plasma.
Conclusions: Our results showed a new strategy to overcome drug resistance by combination of traditional chemotherapy with cold atmospheric plasma.},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/33668}
}