@article{TCR33838,
author = {Congrong Wang and Xiangyang Shao and Xuanyu Zhang and Chunmei Xie and Juanping Yu and Xiao Xu and Jian Yang and Yu Li and Weiwen Xu},
title = {Diagnostic value of glypican-3, arginase-1 and hepatocyte paraffin antigen -1 in differentiating hepatocellular carcinoma from intrahepatic cholangiocarcinoma},
journal = {Translational Cancer Research},
volume = {9},
number = {1},
year = {2019},
keywords = {},
abstract = {Background: The aim of the present study was to investigate the diagnostic value of glypican-3 (GPC3), arginase-1 (Arg-1), and hepatocyte paraffin antigen 1 (HepPar-1) in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC).
Methods: The expression of GPC3, HepPar-1 and Arg-1 were measured by immunohistochemistry in 47 cases of HCC, 29 cases of ICC and their paracancerous tissues.
Results: A high expression of GPC3, Arg-1 and HepPar-1 was observed in HCC tissues (68.09%, 76.60% and 78.72%, respectively; P>0.0125) while it was lower in ICC tissues (6.90%, 6.90% and 13.79%, respectively; P>0.0125). With regard to specificity, GPC3 performed better than Arg-1 and HepPar-1 (97.37% vs. 1.32% and 2.63%, respectively; P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/33838}
}