@article{TCR34025,
author = {Chiming Zhang and Wenqian Zheng and Yiming Lv and Lina Shan and Dengyong Xu and Yangtao Pan and Hongbo Zhu and Haiou Qi},
title = {Postoperative carcinoembryonic antigen (CEA) levels predict outcomes after resection of colorectal cancer in patients with normal preoperative CEA levels},
journal = {Translational Cancer Research},
volume = {9},
number = {1},
year = {2019},
keywords = {},
abstract = {Background: Carcinoembryonic antigen (CEA) is a cancer biomarker used in colorectal cancer (CRC) for tumor screening and outcome prediction. However it is still lack of sensitivity and specificity in general population. The present study aimed to investigate the clinical significance of CEA in patients with normal preoperative CEA levels.
Methods: Ninety-four patients were included who received surgery and developed an elevated CEA level postoperatively. They were divided into group A1 and A2 according to the peak CEA level (whether more than 10 ng/mL); group B1 and B2 according to CEA variation (whether reached a normal level at least once). The association between postoperative CEA and overall survival (OS), and disease-free survival (DFS) were analyzed using Kaplan-Meier method and Cox’s proportional hazards regression model.
Results: The median follow-up time was 38 months. Patients in Group A2 and Group B2 had greater opportunities for recurrence and metastasis (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/34025}
}