@article{TCR34079,
author = {Si-Huai Huang and Yi-Ning Li and Jian-Wei Li and Yi-Hong Guo and Xue-Feng Su},
title = {Widowed status predicts poor overall survival of Chinese patients with prostate cancer},
journal = {Translational Cancer Research},
volume = {9},
number = {2},
year = {2019},
keywords = {},
abstract = {Background: Little is known about the influence of marital status on Chinese prostate cancer (PCa) patients. Marital status may have an impact on overall survival in Chinese men with prostate cancer.
Methods: We identified 4,208 Chinese patients diagnosed with PCa between 2004 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox proportional hazard models were used to determine the impact of marital status on the overall survival (OS) of Chinese PCa patients. Survival analysis was performed using the Kaplan-Meier method. Smoothing function and threshold effect analysis were performed to determine the turning points of variables.
Results: Univariate analysis demonstrated that marital status, prostate-specific antigen (PSA) category, surgery status, T stage, N stage, and M stage were associated with OS. Multivariate analysis further indicated that marital status, PSA category, surgery status, T stage, and M stage were independent risk factors of OS. Survival analysis demonstrated that the nonwidowed group had a better OS than the widowed group. The risk of poor OS increased rapidly with the PSA level up to the turning point 15.6 and 45.4 ng/mL in the nonwidowed group (HR =1.089; 95% CI: 1.064–1.115; P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/34079}
}