@article{TCR34761,
author = {Qing-Yun Duan and Xiong Zhang and Meng Wu and Fu Yu and Mei Xu and Wei-Jie Dong and Min Gan and Min-Song Tu and Hong-Bing Jiang},
title = {Functional analysis of long-chain non-coding RNA in oral squamous cell carcinoma},
journal = {Translational Cancer Research},
volume = {9},
number = {1},
year = {2020},
keywords = {},
abstract = {Background: This study aimed to investigate the expression profile of long-chain non-coding RNA (lncRNA) in oral squamous cell carcinoma (OSCC) and to explore the biological functions of differentially expressed lncRNA in the cancer tissues as compared with adjacent normal tissues, and the differentially expressed lncRNAs related to OSCC were screened.
Methods: High-throughput lncRNA microarray assay was used to detect the expression of lncRNA and mRNA in the OSCC tissues and adjacent normal tissues from five patients. The expression profiles of the lncRNA and mRNA in the cancer tissues and adjacent normal tissues were analyzed and the differentially expressed lncRNA and mRNAs were identified. The differentially expressed mRNA was analyzed with GO, Pathway and disease annotation enrichment database, and the mRNAs related to the tumor and the lncRNA- mRNA co-expression network were employed to screen the key lncRNA related to the occurrence and development of OSCC.
Results: A total of 3,022 differentially expressed lncRNAs and 4,364 differentially expressed mRNAs were identified in the OSCC tissues as compared with adjacent normal tissues. A further analysis revealed 130 major differentially expressed mRNAs related to the tumor. When the correlation was >0.99 or },
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/34761}
}