@article{TCR34850,
author = {Cong Li and Fangqi Liu and Dan Huang and Yuchen Wu and Zhimin Wang and Ye Xu},
title = {The correlation between DNA mismatch repair status and the clinicopathological and molecular features of Chinese sporadic colorectal cancer},
journal = {Translational Cancer Research},
volume = {9},
number = {1},
year = {2020},
keywords = {},
abstract = {Background: DNA mismatch repair (MMR) genes play an important role in cancer development. Deficiencies in these genes may cause microsatellite instability (MSI), which can cause colorectal cancer (CRC). Therefore, we evaluate the relationship between MMR status and the clinicopathological and molecular features of Chinese patients with sporadic CRC.
Methods: We evaluated 1,405 patients who had undergone primary tumour resection, and divided them into MMR deficiency (dMMR) and MMR proficiency (pMMR) groups, according to their MMR gene expressions. All clinicopathological and molecular features were obtained from pathology reports.
Results: The dMMR group contained 125 patients and the pMMR group contained 1 280 patients. Patients with dMMR were more likely to be younger (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/34850}
}