@article{TCR35015,
author = {Maruthi Prasad E. and Ting Liu and Xiang Zhang and Hongli Yang and Jing Wang and Renpeng Huang and Yuhong Wang},
title = {High-mobility group A1 (HMGA1) gene expressions in various colorectal cancer cell lines and correlation with prognosis},
journal = {Translational Cancer Research},
volume = {9},
number = {2},
year = {2020},
keywords = {},
abstract = {Background: The high-mobility group A1 gene (HMGA1) plays a major role in the development of malignant cancers. However, the mechanisms underlying the correlation between HMGA1 expression level and patients’ overall survival rate in various malignant cancers is unclear.
Methods: We used The Cancer Genome Atlas (TCGA) database (https://genome-cancer.ucsc.edu/) to search for mRNA expression levels of HMGA1 in tumor patients and grouped them by receiver operating characteristic (ROC) curve. This divided patients into a high expression cohort and low expression cohort, and Kaplan-Meier analysis revealed the overall survival of the cancer patients. We also used real-time quantitative PCR (qPCR) to detect the expression of HMGA1, CBX7, E-cadherin, and β-catenin gene was detected by normalized to the expression of β-actin in colorectal cancer cell lines.
Results: High expression group correlated with worse survival prognosis statistically significant (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/35015}
}