@article{TCR8229,
author = {Xiu-Jun Chang and Xiao-Shu Zuo and Zi-Tong Wang and Fu-Gen Li and Yong Duan and Ming Han},
title = {The clinical significance of loss of FHIT and PTEN expression in 289 patients with non-small-cell lung cancer},
journal = {Translational Cancer Research},
volume = {5},
number = {3},
year = {2016},
keywords = {},
abstract = {Background: The Fragile histidine triad (FHIT) gene is a nucleotide metabolism associated with the Ap3A hydrolase, which may regulate cell cycle and induce cell apoptosis. Phosphate and tensin homolog deleted on chromosome ten (PTEN) had been found to be a dual specificity phosphatase activity (DSP) of the tumor suppressor gene. However, the roles of FHIT and PTEN in patients with non-small-cell lung cancer (NSCLC) is not well established so far.
Methods: Immunohistochemistry staining was used to determine the expression of FHIT and PTEN in 76 cases of normal lung tissue and benign pulmonary lesion tissues and 289 cases of NSCLC.
Results: The negative rate of FHIT and PTEN expression in NSCLC was significantly higher than that in normal lung tissues and benign pulmonary lesion tissues (P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/8229}
}