@article{TCR8294,
author = {Erica L. Stone and Louise M. D’Cruz},
title = {Tumor-infiltrating T cells are invigorated by modulating cholesterol metabolism},
journal = {Translational Cancer Research},
volume = {5},
number = {Suppl 2},
year = {2016},
keywords = {},
abstract = {CD8+ cytotoxic T cells are fundamental immune cells required for tumor suppression. Under infectious conditions, these cells respond to their corresponding antigen, differentiating to cytotoxic effector T cells. Upon resolution of infection, most effector T cells will undergo contraction while a subset remain, forming immunological memory to protect from subsequent infection. During chronic infection, such as infection with chronic lymphocytic choriomeningitis virus (LCMV), HIV or hepatitis, responding CD8+ T cells will undergo what has been termed ‘exhaustion’, in which these cells rapidly lose effector function (1). Importantly, in the context of the tumor microenvironment, where tumor self-antigen can be considered ‘chronic’, CD8+ T cells also become exhausted, losing effector function and expressing inhibitory receptors such as PD-1 and CTLA-4 (1,2). Reversing exhaustion of tumor infiltrating effector T cells is considered fundamental for tumor eradication and a key focus of cancer immunotherapy (3).},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/8294}
}