@article{TCR8721,
author = {Yun Lin and Zhengting Wang and Jie Zhong and Shurong Hu and Mengmeng Cheng and Tianyu Zhang and Maocheng Zhang and Liwen Hong and Weiguo Cao and Rong Fan},
title = {A retrospective analysis of clinical pathological characteristics and prognosis of 82 patients of primary intestinal lymphoma},
journal = {Translational Cancer Research},
volume = {5},
number = {4},
year = {2016},
keywords = {},
abstract = {Background: To evaluate the histological type, clinical presentation, treatment and prognosis of primary intestinal lymphoma (PIL).
Methods: From 2003 to 2015, in a single institution in China, 82 patients with a diagnosis of PIL were enrolled in our study. According to World Health Organization (WHO) classification and Lugano staging system for gastrointestinal lymphoma, we divided patients into different subtypes and stages.
Results: Male to female ratio was 1.8:1 and the median age was 59.5 years. Of the 82 patients, 68 patients (82.9%) suffered from intestinal B-cell lymphoma (IBCL) and 14 patients (17.1%) suffered from intestinal T-cell lymphoma (ITCL). Diffuse large B cell lymphoma (DLBCL) was the predominant histological subtype (59.8%) in all of the PIL cases. Mucosa-associated lymphoid tissue-type lymphoma (MALT) was the second most common subtype (15.9%). From the study we also concluded that PIL mostly occurred in the small intestine (45.1%), followed by colon and rectum (26.8%). The univariate prognosis analysis revealed that Lugano stage I/II, B-cell phenotype and treatment based on surgery plus chemotherapy were independent prognostic factors (P=0.003, 0.000 and 0.000, respectively). According to multivariate analysis, age of onset, Lugano stage, immunophenotype and the method of treatment were significant predictive factors for better survival (P=0.005, 0.005, 0.000 and 0.000, respectively).
Conclusions: The patients with younger age of onset, B cell lymphoma, earlier stages, and treatment based on surgery plus chemotherapy have a better prognosis. To ensure the diagnosis of PIL to be made as soon as possible, we should make efforts to select the proper laboratory parameters and imaging findings of PIL.},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/8721}
}