@article{TCR8772,
author = {Yasuto Kinose and Kenjiro Sawada and Tadashi Kimura},
title = {Crucial role of vascular endothelial growth factor in the immune system of patients with ovarian cancer},
journal = {Translational Cancer Research},
volume = {5},
number = {Suppl 2},
year = {2016},
keywords = {},
abstract = {Bevacizumab is a recombinant humanized monoclonal IgG1 antibody that targets vascular endothelial growth factor A (VEGF-A) (1). Since the 2000s, several large phase III clinical trials, such as GOG218 and ICON7, have shown that bevacizumab has a drastic effect on ovarian cancer prognosis, in combination with standard chemotherapy (2,3). In patients who showed platinum-sensitive relapse, bevacizumab has also been shown to improve progression-free survival (PFS) (OCEANS) (4), although no overall survival (OS) benefit was found. Furthermore, in platinum-resistant relapse, a recent phase III trial (AURELIA) reported an increase in response rate and a doubling of PFS (6.7 vs. 3.4 months) in patients who received a single agent chemotherapy plus bevacizumab, compared to those who received chemotherapy alone (5). These clinical results show that angiogenesis via VEGF signaling is a crucial contributor to ovarian carcinogenesis and progression. Consequently, bevacizumab has great potential for ovarian cancer treatment. Indeed, it is well known that patients with high VEGF expression have significantly poorer survival rates than those with low VEGF expression (6), and that massive ascites contain aberrant high concentrations of VEGF with peritoneal dissemination in advanced or recurrent ovarian cancer (7). The clinical efficacy of bevacizumab is primarily due to its anti-angiogenic effects; however, recent reports have revealed that it has not only direct antitumor effects but also immunomodulatory effects (8).},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/8772}
}