@article{TCR9464,
author = {Rosina Maria Critelli and Filippo Schepis and Erica Villa},
title = {Akt1/Akt2 inhibition and development of hepatocellular carcinoma},
journal = {Translational Cancer Research},
volume = {5},
number = {Suppl 3},
year = {2016},
keywords = {},
abstract = {The serine/threonine kinase Akt is a key regulator of important normal cellular activities, including survival, proliferation, differentiation, cell size and glucose metabolism. Akt has also a relevant role in the epithelial–mesenchymal transition during development and tumorigenesis and is a pivotal controller of angiogenesis (1,2). When deregulated, Akt can contribute to cancer development, invasion/metastasis and drug resistance acquisition. It is frequently hyper-activated in human cancer and therefore it is considered an attractive target for therapies based on small molecule inhibitors (3).},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/9464}
}