TY  - JOUR
AU  - Critelli, Rosina Maria
AU  - Schepis, Filippo
AU  - Villa, Erica
PY  - 2016
TI  - Akt1/Akt2 inhibition and development of hepatocellular carcinoma
JF  - Translational Cancer Research; Vol 5, Supplement 3 (September 29, 2016): Translational Cancer Research
Y2  - 2016
KW  - 
N2  - The serine/threonine kinase Akt is a key regulator of important normal cellular activities, including survival, proliferation, differentiation, cell size and glucose metabolism. Akt has also a relevant role in the epithelial–mesenchymal transition during development and tumorigenesis and is a pivotal controller of angiogenesis (1,2). When deregulated, Akt can contribute to cancer development, invasion/metastasis and drug resistance acquisition. It is frequently hyper-activated in human cancer and therefore it is considered an attractive target for therapies based on small molecule inhibitors (3).
UR  - https://tcr.amegroups.org/article/view/9464